2021 Fiscal Year Final Research Report

Investigation pf a novel sterilisation method by peroxynitric acid for peri-implant infection

Research Project

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Project/Area Number	18K09685
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 57050:Prosthodontics-related
Research Institution	Kyushu University
Principal Investigator	Esaki Daisuke 九州大学, 歯学研究院, 共同研究員 (10608970)
Co-Investigator(Kenkyū-buntansha)	都留朋子九州大学, 大学病院, 医員 (40823612) 松下恭之九州大学, 大学病院, 准教授 (60159150) 鮎川保則九州大学, 歯学研究院, 教授 (50304697) 古谷野潔九州大学, 歯学研究院, 特別教員 (50195872) 神野洋平九州大学, 大学病院, 助教 (40507779)
Project Period (FY)	2018-04-01 – 2022-03-31
Keywords	歯科インプラント治療 / インプラント周囲炎 / 過硝酸
Outline of Final Research Achievements	This research evaluated the bactericidal effects of peroxynitric acid (HOONO2; PNA) on biofilms formed on titanium surfaces. Streptococcus gordonii was cultured on titanium discs that were then used to evaluate the bactericidal effects of PNA. Using low concentration of PNA, the bacterial count based on a CFU assay reached an undetectable level within 10 s.Bacillus subtilis solution was coated on the dental model, and impression taking of the model was done by dental impression material. Dental impression material was disinfected by PNA, and bactericidal effects were evaluated. The bacterial count based on a CFU assay reached an undetectable level within 10 minutes. PNA is useful for sterilizing biofilms on titanium surfaces and dental impression material that have been contaminated with bacteria.
Free Research Field	歯科インプラント
Academic Significance and Societal Importance of the Research Achievements	歯科インプラント治療は歯科補綴治療の選択肢として需要な位置を占める治療法である。しかし、近年インプラント周囲炎の問題が大きく取り上げられており、その治療法についても絶対的な方法はない。そこで過硝酸の殺菌効果に着目し、インプラント周囲炎の治療法に応用するための基礎実験を行い、良好な結果を得た。過硝酸の歯科材料の消毒への応用を目指した基礎実験も行い、良好な結果を得た。