Search for novel personalized therapies targeting the PDE2 intracellular signaling complex in malignancies

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K09720
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57060:Surgical dentistry-related
• Research Institution: Mie University
• Principal Investigator: MURATA TAKU 三重大学, 医学部附属病院, 講師 (80242965)
• Co-Investigator(Kenkyū-buntansha): 清水 香澄 三重大学, 医学部附属病院, 講師 (20378368)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: phosphodiesterase / cAMP / melanoma

Outline of Final Research Achievements

Phosphodiesterase (PDE) regulates intracellular concentrations by degrading enzymes of intracellular signal transduction substances cAMP and cGMP, and is involved in various physiological actions. There are 11 types of isozymes from PDE1 to PDE11 in PDE. We have reported for the first time in the world that PDE2, one of the PDE isozymes, is associated with invasion. It is considered that one amino acid of the PDE2 protein is changed by mutation of a specific site of the PDE2 gene., and as a result, the intracellular localization of the PDE2 protein is changed. In this study, we found that the expression level of mutants may regulate localization and invasion.

Free Research Field

口腔・顎顔面外科

Academic Significance and Societal Importance of the Research Achievements

本研究の成果によりPDE2の基礎的研究をさらに進め、PDE2の遺伝子異常に対する分子標的薬の開発やPDE2細胞内情報伝達複合体を利用した新しい診断方法や個別化治療への臨床応用に道を開くことに学術的意義や社会的意義がある。