Peripheral and central intervention to pain during orthodontic tooth movement

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K09843
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Meikai University
• Principal Investigator: SUDA Naoto 明海大学, 歯学部, 教授 (90302885)
• Co-Investigator(Kenkyū-buntansha): 村本 和世 明海大学, 歯学部, 教授 (10301798) ; 安達 一典 明海大学, 歯学部, 教授 (20349963) ; 坂上 宏 明海大学, 歯学部, 教授 (50138484)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 歯の移動 / 疼痛 / TRPV1

Outline of Final Research Achievements

The effects of topical administration of TRPV1 and / or TRPA1 antagonists to　cervical gingiva on the orthodontic force induced pain and the trigeminal excitability were examined. Each TRP antagonist expressed an analgesic effect on orthodontic force induced pain; however, trigeminal excitation (e.g., GFAP expression in ganglia) was not inhibited. Moreover, the co-administration of both TRP antagonists significantly increased the analgesic effect without inducing temperature alteration. Taken together, the cooperative effect of TRP antagonists may play a critical role in controlling orthodontic force-induced pain.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

矯正力負荷に伴う疼痛と三叉神経節活性に対するTRPV1とTRPA1拮抗薬の歯肉塗布の効果を検討した．その結果，いずれの拮抗薬も矯正装置装着後1日後に塗布することで，単独で用量依存的に鎮痛効果を発現した．しかし，その効果は先行研究のTRPV1拮抗薬全身投与やレーザー照射と比較して有意に低く，三叉神経節のGFAP発現も抑制されなかった．しかしながら，両者を併用することで鎮痛効果は有意に増強され，TRPV1拮抗薬の全身投与やレーザー照射と同等の効果を得ることが出来た．また，その際に，歯肉溝温度と直腸温に変化はみられず，矯正臨床における疼痛制御への有効性が示された．