Development of novel therapy for lifestyle-related diseases of elderly

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K10044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: University of Toyama
• Principal Investigator: Inadera Hidekuni 富山大学, 学術研究部医学系, 教授 (10301144)
• Co-Investigator(Kenkyū-buntansha): 崔 正国 福井大学, 学術研究院医学系部門, 講師 (90572115)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 生活習慣病

Outline of Final Research Achievements

Hyperthermia (HT) has been used as mild anticancer therapy. However, HT alone is insufficient to completely kill tumor cells and an additional agent is required to overcome. In the present study, we have screened and identified several natural compounds as an adjunctive therapy to HT to induce cell death. We also explored the molecular mechanisms involved.

Free Research Field

衛生学、公衆衛生学、予防医学

Academic Significance and Societal Importance of the Research Achievements

高齢者のがん治療は、病気と共存してQOLを長く維持するという視点が重要である。天然資源由来化合物は合成化合物よりも一般的に副作用が低く、高齢者にも投与しやすい。本研究により見出したがん細胞の温熱誘発細胞死を増強する化合物の有効性について、動物実験等により検証を加えることにより、身体にやさしいがん治療法の開発が期待できる。