Relationship between adipocyte-fatty acid binding protein levels and metabolic syndrome in community-dwelling population

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K10094
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Kurume University
• Principal Investigator: Enomoto Mika 久留米大学, 医学部, 講師 (10360281)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 住民検診 / メタボリック症候群 / インスリン抵抗性 / 脂肪酸結合タンパク

Outline of Final Research Achievements

Adipocyte-fatty acid binding protein (A-FABP) is a major cytoplasmic protein in adipocytes, and plays a key role in linking obesity and in the development of diabetes in experimental animals. However, it is still not fully understood the association between A-FABP levels and metabolic syndrome in an epidemiological study. We evaluated the relationship between A-FABP and metabolic syndrome in a general population. We measured serum A-FABP levels by ELISA. Mean A-FABP levels were 17.6 (range 5.5-92.6) ng/ml. When A-FABP levels were stratified by the number of the components of metabolic syndrome, there was a strong association between A-FABP levels and the number of components (p=0.0012) after adjustment for age and gender. In conclusion, this study demonstrated serum A-FABP levels were associated with metabolic syndrome. A-FABP may be a useful biomarker for clinical practice of obesity-related metabolic syndrome.

Free Research Field

社会医学

Academic Significance and Societal Importance of the Research Achievements

一般住民におけるA-FABPの分布を示し、A-FABPと脂質・インスリン抵抗性・メタボリック症候群との関連を横断的に研究するとともに、脳・心血管死の原因であるインスリン抵抗性およびメタボリック症候群の進展との関連を検討する縦断的研究も行う。A-FABPがメタボリック症候群を予知でき、健康管理に役立てられることを示すことで、日常臨床的で応用可能なアイテムとなるか考察することが目的である。