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2020 Fiscal Year Research-status Report

The effects of connectin (titin) on muscle and joint function before and after eccentric contractions

Research Project

Project/Area Number 18K10832
Research InstitutionHosei University

Principal Investigator

越智 英輔  法政大学, 生命科学部, 准教授 (90468778)

Co-Investigator(Kenkyū-buntansha) 中里 浩一  日本体育大学, 保健医療学部, 教授 (00307993)
菊池 直樹  日本体育大学, 体育学部, 准教授 (10739478)
Project Period (FY) 2018-04-01 – 2022-03-31
Keywords遺伝子多型 / 関節柔軟性 / タイチン / コネクチン / 筋硬度 / 筋損傷
Outline of Annual Research Achievements

本年度は、コネクチン(TITIN)遺伝子多型別に筋損傷の程度が異なるかを、筋硬度、関節柔軟性、筋力、筋痛のみならず尿や血液サンプルなどの解析から分析することを目的とした。あわせて動物実験に関しては、分担研究者とラットあるいはマウスのヒト型SNPモデルを完成し、筋損傷実験を開始することを予定していた。しかしコロナウイルスの影響で実験を延期せざるを得なかった。年度末にヒト実験を実施したため、現在解析中である。

Current Status of Research Progress
Current Status of Research Progress

4: Progress in research has been delayed.

Reason

コロナウイルスの影響で実験を延期せざるを得なかった。

Strategy for Future Research Activity

年度末に実施したヒト実験の解析を進めるとともに分担研究者と共に遺伝子改変ラットの作成を完了する。

Causes of Carryover

コロナウイルスの影響で予定通りに実験が遂行できなかったため。次年度は延期した実験にかかる消耗品、人件費に研究費を充てる。

  • Research Products

    (10 results)

All 2021 2020

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 6 results)

  • [Journal Article] Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis2021

    • Author(s)
      Tidball James G.、Flores Ivan、Welc Steven S.、Wehling-Henricks Michelle、Ochi Eisuke
    • Journal Title

      Experimental Gerontology

      Volume: 145 Pages: 111200~111200

    • DOI

      10.1016/j.exger.2020.111200

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Plasma Eicosapentaenoic Acid Is Associated with Muscle Strength and Muscle Damage after Strenuous Exercise2021

    • Author(s)
      Ochi Eisuke、Yanagimoto Kenichi、Tsuchiya Yosuke
    • Journal Title

      Sports

      Volume: 9 Pages: 11~11

    • DOI

      10.3390/sports9010011

    • Peer Reviewed / Open Access
  • [Journal Article] High-intensity interval training in breast cancer survivors: a systematic review2021

    • Author(s)
      Tsuji Katsunori、Matsuoka Yutaka J.、Ochi Eisuke
    • Journal Title

      BMC Cancer

      Volume: 21 Pages: 184

    • DOI

      10.1186/s12885-021-07804-w

    • Peer Reviewed / Open Access
  • [Journal Article] 4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions2021

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Yanagimoto Kenichi、Kato Ayaka、Ochi Eisuke
    • Journal Title

      Journal of the International Society of Sports Nutrition

      Volume: 18 Pages: 18

    • DOI

      10.1186/s12970-021-00411-x

    • Peer Reviewed / Open Access
  • [Journal Article] Low Dose of β-Hydroxy-β-Methylbutyrate (HMB) Alleviates Muscle Strength Loss and Limited Joint Flexibility following Eccentric Contractions2020

    • Author(s)
      Tsuchiya Yosuke、Ueda Hisashi、Sugita Naoki、Ochi Eisuke
    • Journal Title

      Journal of the American College of Nutrition

      Volume: 40 Pages: 211~218

    • DOI

      10.1080/07315724.2020.1752330

    • Peer Reviewed
  • [Journal Article] Data Validation and Verification Using Blockchain in a Clinical Trial for Breast Cancer: Regulatory Sandbox2020

    • Author(s)
      Hirano Tomonobu、Motohashi Tomomitsu、Okumura Kosuke、Takajo Kentaro、Kuroki Taiyo、Ichikawa Daisuke、Matsuoka Yutaka、Ochi Eisuke、Ueno Taro
    • Journal Title

      Journal of Medical Internet Research

      Volume: 22 Pages: e18938~e18938

    • DOI

      10.2196/18938

    • Peer Reviewed / Open Access
  • [Journal Article] Sitting-induced Endothelial Dysfunction Is Prevented in Endurance-trained Individuals2020

    • Author(s)
      MORISHIMA TAKUMA、TSUCHIYA YOSUKE、UEDA HISASHI、TSUJI KATSUNORI、OCHI EISUKE
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 52 Pages: 1770~1775

    • DOI

      10.1249/MSS.0000000000002302

    • Peer Reviewed
  • [Journal Article] Muscular endurance and muscle metabolic responses to 8 weeks of omega‐3 polyunsaturated fatty acids supplementation2020

    • Author(s)
      Morishima Takuma、Tsuchiya Yosuke、Ueda Hisashi、Ochi Eisuke
    • Journal Title

      Physiological Reports

      Volume: 8 Pages: e14546

    • DOI

      10.14814/phy2.14546

    • Peer Reviewed / Open Access
  • [Journal Article] Maintenance of endothelial function following acute resistance exercise in females is associated with a tempered blood pressure response2020

    • Author(s)
      Morishima Takuma、Padilla Jaume、Tsuchiya Yosuke、Ochi Eisuke
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Pages: 792~799

    • DOI

      10.1152/japplphysiol.00378.2020

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fast-Velocity Eccentric Cycling Exercise Causes Greater Muscle Damage Than Slow Eccentric Cycling2020

    • Author(s)
      Ueda Hisashi、Tsuchiya Yosuke、Ochi Eisuke
    • Journal Title

      Frontiers in Physiology

      Volume: 11 Pages: 596640

    • DOI

      10.3389/fphys.2020.596640

    • Peer Reviewed / Open Access

URL: 

Published: 2021-12-27  

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