2023 Fiscal Year Final Research Report

Effects of physical exercise on the regulation of adult stem cells existed independently in separate organs

Research Project

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Project/Area Number	18K10879
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 59020:Sports sciences-related
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	kuwabara tomoko 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (90358391)
Co-Investigator(Kenkyū-buntansha)	藤巻慎熊本大学, 発生医学研究所, 助教 (10795678)
Project Period (FY)	2018-04-01 – 2024-03-31
Keywords	幹細胞 / サルコペニア / 神経科学 / 認知機能 / 老化 / 骨格筋 / サテライト細胞 / 組織幹細胞
Outline of Final Research Achievements	For adult stem cells, the effect of exercise without inflammatory reactions promotes proliferation. When comparing neural stem cells and skeletal muscle stem cells as adult stem cells, the expression of regulatory factors from niche cells of neural stem cells in the brain hippocampus increased depending on the exercise effect, and had a promoting effect on neurogenesis. There are many unknown areas regarding the role of satellite cells in adult skeletal muscle in disease and aging processes, and the response mechanisms to the effects of preventive exercise. Under conditions where muscle hypertrophy or muscle atrophy occurs due to exercise, we analyzed in which regions the expression and function change, and whether or not it affects the function of satellite cells. We analyzed the transformation mechanisms of adult stem cells in the brain and skeletal muscle in parallel, conducted comparative research on the behavior of related factors, and pursued knowledge from a new perspective.
Free Research Field	スポーツ医化学
Academic Significance and Societal Importance of the Research Achievements	我々は多種類の成体幹細胞を扱って、機能解析研究を実施してきた。骨格筋のサテライト細胞と脳神経系の神経幹細胞で、運動効果による機能応答に制御因子がどのような役割を担うのか、動態について解析を行った。筋肉は再生能力が優れていて、サテライト細胞の持つ老化に対する予防効果などその潜在能力は高い。外的刺激には、幹組織機能を上昇する変化もあれば、減少させる物理的環境変化（ex.寝たきり、老化など）もある。各組織の成体幹細胞やニッチには、運動という生体全体への刺激に効率よく応答するメカニズムがあり、その両者をパラレルに研究することで、サルコペニアへの予防法につながる一端が見えてきた。