Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K11119
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Tokyo University of Science, Yamaguchi
• Principal Investigator: OKITA Naoyuki 山陽小野田市立山口東京理科大学, 薬学部, 講師 (60453841)
• Co-Investigator(Kenkyū-buntansha): 樋上 賀一 東京理科大学, 薬学部生命創薬科学科, 教授 (90253640) ; 柴田 淳史 群馬大学, 未来先端研究機構, 准教授 (30707633)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 2型糖尿病 / 膵島 / 分化転換 / 機能疲弊

Outline of Final Research Achievements

In the present study, we tried to establish the molecular basis of transdifferentiation of β cells in type 2 diabetes mellitus by elucidating " dependency of functional exhaustion on transdifferentiation" and "versatility of transdifferentiation". MIN6c4 cells, a mouse pancreatic β cell line, treated with high glucose and a certain type of fatty acid were subjected to various analysis from perspectives of acute or chronic stress. The most important result is data from transcriptome analysis which show differential expression pattern between acute and chronic stress.

Free Research Field

代謝ストレス応答

Academic Significance and Societal Importance of the Research Achievements

これまでの当該分野での研究手法に一石を投じることが期待される。また、本研究の推進は、糖尿病研究における動物実験の代替方法の確立の側面も有することは時代の流れにも沿った研究であると言える。