2020 Fiscal Year Final Research Report
Study on the effect of food on the expression of serum microRNAs
| Project/Area Number |
18K11124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
深津 佳世子 (佐々木) 共立女子大学, 家政学部, 教授 (70338903)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 血中microRNA / 食品 |
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| Outline of Final Research Achievements |
The aim of this study was to determine if changes in blood microRNAs (miRNAs) could be a marker of food functionality. In a randomized controlled trial (RCT) comparing a brown rice diet with a white rice diet, significant differences in expression were found between the brown and white rice groups for four of 176 miRNAs. In an RCT comparing BCAA supplementation with soy protein supplementation, changes were observed in 16 of 768 miRNAs, two of which moved in opposite directions in the two groups. For some of the miRNAs that were altered in the two studies, there was a correlation between changes in miRNA expression and changes in metabolic status.
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| Free Research Field |
応用健康科学
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| Academic Significance and Societal Importance of the Research Achievements |
血中microRNA (miRNA) の変化は、がん患者でも認められ、特定のがんをターゲットとしたmiRNAのパネルも発売されている。今回の研究成果により、血中miRNAの変化が食品によってもたらされる代謝状態の変化の一部を反映していることが示された。これまでは、動物実験や細胞を用いた実験で機能を推定していたが、これらによって示された効果が、必ずしもヒトに投与した場合に再現できないことも多く、血清miRNAによるliquid biopsyは、食品の機能性のみならず、薬品などの機能性を評価するのにも有用であると考えられた。
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