Development of innovative cancer therapy by opening of tumor neovasculature

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K12060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 90110:Biomedical engineering-related
• Research Institution: Tottori University
• Principal Investigator: OSAKI Tomohiro 鳥取大学, 農学部, 准教授 (40431332)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: リピッドバブル / 薬物送達 / 腫瘍 / イヌ

Outline of Final Research Achievements

In an in vivo experiment, we clarified that the combined use of lipid bubbles and low-intensity ultrasound enhanced the accumulation of pegylated liposomal doxorubicin hydrochloride in tumor tissues, thereby increasing its antitumor effect. In a veterinary clinical experiment on unresectable canine solid tumors, we found that that abovementioned triple-combination therapy induced a notable reduction in tumor volume. These findings indicate that lipid bubbles, in combination with chemotherapeutic agents and low-intensity ultrasound irradiation, have potential therapeutic applications for the treatment of canine tumors.

Free Research Field

腫瘍

Academic Significance and Societal Importance of the Research Achievements

リピッドバブルの投与と超音波照射により、同時に投与した抗がん剤を腫瘍組織内に効率よく送達することができ、抗腫瘍効果を増強させることができた。これは、投与する抗がん剤の投与量を減少させることができるため、薬剤の副作用を軽減することができることを意味する。本研究結果は、ヒト医療への橋渡し研究として十分意義のあるものである。