2020 Fiscal Year Final Research Report
Developing brain-penetrating anti-inflammatory nano-medicines to treat neurodegenerative diseases
| Project/Area Number |
18K14100
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 28040:Nanobioscience-related
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| Research Institution | Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine |
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Principal Investigator |
Gonzalez Carter Daniel Angel 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (80800903)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | Nanoparticles / Brain / Blood-brain barrier / Glucose / Alzheimer's |
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| Outline of Final Research Achievements |
We created a nano-carrier system capable of delivering therapeutic payloads specifically into the brain. We designed nanoparticles decorated with glucose (G-NP) capable of encapsulating therapeutic antibodies. By modulating blood-glucose levels, we were able to induce movement of the glucose transporter Glut-1 specifically across brain endothelial cells (BEC). Hence, the G-NP bound to the Glut-1 were transported across BEC to release their therapeutic cargo specifically in the brain. We demonstrated the therapeutic potential of this strategy by delivering antibodies capable of preventing aggregation of amyloid-beta, a key pathological mechanism in Alzheimer's disease.
We also developed a new brain-targeting strategy which exploits the impermeability of the blood-brain barrer to selectively label BEC. This strategy has the benefit that it does not modify the physiology of the organism, therefore has great potential for clinical translation.
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| Free Research Field |
Biomedical research/bioengineering
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| Academic Significance and Societal Importance of the Research Achievements |
Treating neurodegenerative diseases is severely limited by the poor entry of therapies into the brain. We have developed two different strategies capable of delivering nanoparticles specifically to the brain, thereby paving the way to deliver a wide-range of therapies into the brain.
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