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2020 Fiscal Year Final Research Report

High-sensitivity detection of cancer mutant tumor markers by pipette-tip assay system

Research Project

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Project/Area Number 18K14252
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 34020:Analytical chemistry-related
Research InstitutionKobe University

Principal Investigator

TAKANO eri  神戸大学, 工学研究科, 学術研究員 (20634645)

Project Period (FY) 2018-04-01 – 2021-03-31
Keywords分子認識 / バイオマーカー / 表面プラズモン励起増強蛍光 / 分子インプリンティング / 全自動分析装置
Outline of Final Research Achievements

In this study, prostate-specific antigen (PSA), which is a biomarker glycoprotein for prostate cancer, was used as a model. We tried to recognize sugar chains of PSA to detect the cancer-related PSA by fluorescent molecularly imprinted polymers bearing fluorescent signaling sites (F-MIPs). Antibodies for glycan are difficult to prepare, therefore, F-MIPs could be useful for the substitution of antibodies for glycoproteins.

Free Research Field

分析化学

Academic Significance and Societal Importance of the Research Achievements

SPFセンシングは、従来の蛍光に比べて数十倍から数百倍の高感度で検出できるので、このセンシングが実現できれば、これまで見過ごされてきた擢患初期の情報を得ることがき、学術的に意義がある。また、進行した癌の動態の把握のみならず、早期診断あるいは予後診断のためにも有効で、社会的にも波及効果がある。

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Published: 2022-01-27   Modified: 2024-01-30  

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