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2021 Fiscal Year Annual Research Report

Verification of the functional role of coacervate droplets in in vitro RNA evolution

Research Project

Project/Area Number 18K14354
Research InstitutionTokyo Institute of Technology

Principal Investigator

ジャー トニーズィ  東京工業大学, 地球生命研究所, 特任助教 (10800328)

Project Period (FY) 2018-04-01 – 2022-03-31
KeywordsOrigins of Life / Prebiotic Chemistry / Astrobiology / Protocell
Outline of Annual Research Achievements

I completed the final manuscripts and published some remaining papers related to the original project. Mostly, the experimental aspect was completed, so most of the activity was to complete the final publication of the remaining papers, including some of the following
[1] Eiichiro Mori, Tony Z. Jia*. Editorial: Biological Phase Separation. Frontiers in Genetics, 13, Accpted (2022); [2] Tony Z. Jia*, Shota Nishikawa, Kosuke Fujishima. Sequencing the Origin of Life. BBA Advances, 2, 100049 (2022); [3] Mahendran Sithamparam, Nirmell Satthiyasilan, Chen Chen, Tony Z Jia*, Kuhan Chandru*. A Material-based Panspermia Hypothesis: The Potential of Polymer Gels and Membraneless Droplets. Biopolymers, e23486 (2022); [4] Tony Z. Jia*, Yutetsu Kuruma. Increasing complexity of primitive compartments. Biophysics and Physicobiology, 18, 269-273 (2021); [5] Tony Z. Jia*, Po-Hsiang Wang, Tatsuya Niwa, Irena Mamajanov. Connecting Primitive Phase Separation to Biotechnology, Synthetic Biology, and Engineering. Journal of Biosciences, 46, 79 (2021); [6]Tony Z. Jia*, Tommaso P. Fraccia. Liquid Crystal Phase Assembly in Peptide-DNA Coacervates as a Mechanism for Primitive Emergence of Structural Complexity. Proceedings of the ALIFE 2021: The 2021 Conference on Artificial Life, 56 (2021).


Additionally, I presented the completed research at a number of international and domestic conferences as an invited speaker.

  • Research Products

    (29 results)

All 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 10 results,  Invited: 5 results) Remarks (4 results) Funded Workshop (2 results)

  • [Int'l Joint Research] ESPCI(フランス)

    • Country Name
      FRANCE
    • Counterpart Institution
      ESPCI
  • [Int'l Joint Research] National Central University(Taiwan)

    • Country Name
      その他の国・地域
    • Counterpart Institution
      National Central University
  • [Int'l Joint Research] UKM(マレーシア)

    • Country Name
      MALAYSIA
    • Counterpart Institution
      UKM
  • [Journal Article] Editorial: Biological Phase Separation2022

    • Author(s)
      Eiichiro Mori, Tony Z. Jia
    • Journal Title

      Frontiers in Genetics

      Volume: - Pages: -

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A material‐based panspermia hypothesis: The potential of polymer gels and membraneless droplets2022

    • Author(s)
      Sithamparam Mahendran、Satthiyasilan Nirmell、Chen Chen、Jia Tony Z.、Chandru Kuhan
    • Journal Title

      Biopolymers

      Volume: - Pages: e23486

    • DOI

      10.1002/bip.23486

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sequencing the origins of life2022

    • Author(s)
      Jia Tony Z.、Nishikawa Shota、Fujishima Kosuke
    • Journal Title

      BBA Advances

      Volume: 2 Pages: 100049

    • DOI

      10.1016/j.bbadva.2022.100049

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Liquid Crystal Phase Assembly in Peptide-DNA Coacervates as a Mechanism for Primitive Emergence of Structural Complexity2021

    • Author(s)
      Jia Tony Z.、Fraccia Tommaso P.
    • Journal Title

      Proceedings of the ALIFE 2021: The 2021 Conference on Artificial Life

      Volume: - Pages: 56

    • DOI

      10.1162/isal_a_00362

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Connecting primitive phase separation to biotechnology, synthetic biology, and engineering2021

    • Author(s)
      Jia Tony Z、Wang Po-Hsiang、Niwa Tatsuya、Mamajanov Irena
    • Journal Title

      Journal of Biosciences

      Volume: 46 Pages: 79

    • DOI

      10.1007/s12038-021-00204-z

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increasing complexity of primitive compartments2021

    • Author(s)
      Jia Tony Z.、Kuruma Yutetsu
    • Journal Title

      Biophysics and Physicobiology

      Volume: 18 Pages: 269~273

    • DOI

      10.2142/biophysico.bppb-v18.032

    • Peer Reviewed / Open Access
  • [Presentation] From the Origins of Life to the First Cells: Case Studies from Primitive Phase Separated Membraneless Compartments2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Phase Separated Systems in the Nucleus
    • Int'l Joint Research / Invited
  • [Presentation] From the Origins of Life to the First (Membraneless) Cells2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      MBG Turkey AGENASTRO Congress
    • Int'l Joint Research / Invited
  • [Presentation] Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Japan Geophysical Union
    • Invited
  • [Presentation] From the Origins of Life to the First Cells: Case Studies from Membraneless Protocell Models2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Japanese Society for Biological Sciences in Space Annual Meeting
    • Invited
  • [Presentation] Assembly of Peptide-DNA liquid crystal coacervates as primitive compartments2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      International Society for the Study of the Origin of Life Meeting
    • Int'l Joint Research / Invited
  • [Presentation] Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      American Chemical Society Spring Meeting
    • Int'l Joint Research
  • [Presentation] DNA Liquid Crystal Coacervates and Other Phase-Separated Systems as Primitive Compartments2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Israel Society for Astrobiology and the Study of the Origin of Life 2021
    • Int'l Joint Research
  • [Presentation] Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      BlueSciCon
    • Int'l Joint Research
  • [Presentation] From the Origins of Life to the First Cells2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Tokyo International Exchange Center 69th Research and Presentation
  • [Presentation] Liquid Crystal Phase Assembly in Peptide-DNA Coacervates as a Mechanism for Primitive Emergence of Structural Complexity2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Alife 2021 Meeting
    • Int'l Joint Research
  • [Presentation] DNA liquid crystal coacervates and other membraneless droplets as primitive compartments2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      JSPS-CAS Bilateral Seminar
    • Int'l Joint Research
  • [Presentation] Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      AbGradCon 2021
    • Int'l Joint Research
  • [Presentation] Assembly and Structure of Primitive Membraneless DNA Liquid Crystal Coacervates2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      Fall Meeting of the Polymer Society of Korea
    • Int'l Joint Research
  • [Presentation] Liquid crystal coacervates and polyester microdroplets as primitive membraneless compartments2021

    • Author(s)
      Tony Z. Jia
    • Organizer
      ELSI Assembly
  • [Remarks] ELSI Research Highlight

    • URL

      http://www.elsi.jp/en/news_events/highlights/2021/species_formed_prior_origin_life

  • [Remarks] EARLY EARTH DROPLETS AND THE ORIGINS OF LIFE.

    • URL

      https://issuu.com/asiaresearchnews/docs/asia_research_news_2021/s/12141608

  • [Remarks] Tokyo Tech Press Release

    • URL

      https://www.titech.ac.jp/english/news/2021/061099

  • [Remarks] SYFY Wire News Article

    • URL

      https://www.syfy.com/syfywire/we-might-have-finally-found-out-how-life-formed-on-earth

  • [Funded Workshop] ELSI-UKM Workshop2022

  • [Funded Workshop] JSPS Bilateral JSPS/CAS Seminar "Geoelectrochemical Drivers of Deep Sea Biochemical Processes"2021

URL: 

Published: 2022-12-28  

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