2020 Fiscal Year Annual Research Report
Exploration of new methods to increase homocarnosine in skeletal muscle and their physiological functions
| Project/Area Number |
18K14407
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| Research Institution | Hiroshima University |
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Principal Investigator |
カムランシー タナッチャポーン 広島大学, 統合生命科学研究科(生), 准教授 (90781849)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | Homocarnosine / Carnosine / Skeletal muscle / Muscle regeneration / sarcopenia / Satellite cells |
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| Outline of Annual Research Achievements |
In 2020, we found that homocarnosine and its derivative imidazole dipeptides (carnosine and anserine) are involved in muscle regeneration process. After the muscle injury by cardiotoxin injection, those imidazole dipeptides in the skeletal muscles were rapidly degraded within 12 hr, a long with an up-regulation of its degrading enzyme (carnosinase), while muscle-protein amino acids were not released until 48 hr after the muscle injury. This suggests that imidazole peptides may be involved in energy metabolism in the acute phase during skeletal muscle injury. This suggests a physiological function that protects against excessive degradation of skeletal muscle proteins in sarcopenia.
In addition to the above finding, we found that imidazole dipeptides, carnosine and homocarnosine, possibly prevent cell death of satellite cells upon being activated, implying that these imidazole peptides had a function in supporting satellite cells to undergo myogenesis more efficiently.
These findings suggest new roles of imidazole dipeptides in muscle functions and preventing sarcopenia.
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Research Products
(8 results)
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[Journal Article] Low-dose ethanol has impacts on plasma levels of metabolites relating to chronic disease risk in samp8 mice2020
Author(s)
Fu, C, Yang, Y, Kumrungsee, T, Kimoto, A, Izu, H, Kato, N
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 66
Pages: 553-560
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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