The roles of CRTH2 in IgE production

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K14603
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 42030:Animal life science-related
• Research Institution: The University of Tokyo
• Principal Investigator: Nakamura Tatsuro 東京大学, 大学院農学生命科学研究科(農学部), 特任講師 (80755554)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: IgE / CRTH2 / PGD2

Outline of Final Research Achievements

IgE antibody is an essential molecule for the induction of allergic diseases. We found that CRTH2, a receptor for PGD2, promotes IgE production by enhancement of dendritic cells activity and follicular T cell differentiation. Pharmacological inhibition of CRTH2 inhibits the increase of IgE level. CRTH2 inhibitor could be a target for the development of new therapeutic strategy for allergic diseases.

Free Research Field

アレルギー

Academic Significance and Societal Importance of the Research Achievements

アレルギー疾患を根治に導くためにはIgE抗体産生を抑制する必要があるが、その方法は未だ確立されていない。本研究ではプロスタグランジンD2の受容体の一つであるCRTH2がIgE抗体産生を促進する分子メカニズムの一端を明らかにした。CRTH2阻害剤の新規抗アレルギー薬としての可能性を示した。