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2019 Fiscal Year Final Research Report

Development of comprehensive analytical system for lipid derived aldehydes

Research Project

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Project/Area Number 18K14884
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Research InstitutionKyushu University

Principal Investigator

Matsuoka Yuta  九州大学, 薬学研究院, 助教 (20783509)

Project Period (FY) 2018-04-01 – 2020-03-31
Keywordsフリーラジカル / 酸化ストレス疾患
Outline of Final Research Achievements

Lipid derived aldehydes have been recognized as significant bioactive substances in the pathogenesis of several oxidative diseases. However, due to the complexities of lipid peroxidation mechanisms, the number of identified lipid aldehydes remains low. Here, we performed the comprehensive identification of lipid aldehydes by applying the analytical system for lipid radicals, and constructed a database of a total of 140 lipid aldehydes. Using this technique, we achieved the comprehensive analysis of lipid aldehydes produced in oxidized low density lipoprotein.

Free Research Field

脂質過酸化反応

Academic Significance and Societal Importance of the Research Achievements

疾患発症時における脂質アルデヒドの重要性はかねてより、多くの研究者の間で議論されてきた。しかしながら、その構造情報が不足していたため、具体的にどのようなアルデヒド種が増減しているかは不明であった。一方、我々が新たに提唱した脂質アルデヒド解析手法は、反応系中において生成する様々な脂質アルデヒドを体系的に評価することができる。このため、本手法を今後さらに応用することで、「脂質の酸化反応」に焦点を当てた新たなバイオマーカー探索および疾患メカニズム解明が期待される。

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Published: 2021-02-19  

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