RNA editing-mediated regulation of PXR and CAR

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K14901
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Kanazawa University
• Principal Investigator: Nakano Masataka 金沢大学, 薬学系, 助教 (00816225)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 薬物代謝 / RNA編集 / 転写後修飾

Outline of Final Research Achievements

Adenosine deaminases acting on RNA (ADAR) 1 and ADAR2 enzymes-catalyzing A-to-I RNA editing possibly modulates gene expression and function. In this study, we found that ADAR regulate the expression of human　pregnane X receptor and constitutive androstane receptor, which controls the expression of various drug-metabolizing enzymes. RNA editing enzymes ADAR1 and ADAR2 would be novel regulatory factors of drug metabolism potencies in the human liver.

Free Research Field

薬物代謝学

Academic Significance and Societal Importance of the Research Achievements

薬物治療において認められる薬効や副作用には大きな個人差の原因なりうる、adenosine deaminases acting on RNA (ADAR) 1とADAR2が触媒するA-to-I RNAによる核内受容体PXRとCARの発現制御を明らかにした。個別化医療の実現に向けた基盤情報となる、ヒト薬物代謝能の新規制御メカニズムを明らかにすることが出来た。