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2019 Fiscal Year Final Research Report

Anomaly detection of drug-adverse events from large-scale database: data-driven analysis with machine learning

Research Project

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Project/Area Number 18K14950
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionKyoto University

Principal Investigator

Takeuchi Masato  京都大学, 医学研究科, 准教授 (80598714)

Project Period (FY) 2018-04-01 – 2020-03-31
Keywords薬剤疫学 / 機械学習 / 時系列データ
Outline of Final Research Achievements

We explored whether, using machine learning techniques, automated anomaly detection of drug-adverse events was feasible from large-scale database (eg, claims data). We selected two case examples; the first example was SGLT-2 inhibitor and its adverse events such as renal insufficiency or dehydration, and the second one was bisphosphonate and osteonecrosis of the jaw. Machine learning techniques successfully detected the anomaly points from a time-series data of large-scale database. However, the detected anomaly points were sensitive to the model or the administrative code selection of adverse event.

Free Research Field

薬剤疫学

Academic Significance and Societal Importance of the Research Achievements

病名の入力に関しては医療機関・医師レベルにより方針が異なるのが日本の実情と思われる。機械学習を用いた検出においても、その精密さはこれら診療プラクティスの違いに大きく依存した。したがって、この技術を実用面で用いる前提として、病名入力の方針について何らかの統一的な指針を整備することが必要であることを示唆した研究である。

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Published: 2021-02-19  

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