2021 Fiscal Year Final Research Report
Evaluation of pharmacokinetics of cancer drugs in patients with renal dysfunction and establishment of administration methods
| Project/Area Number |
18K15277
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Keywords | がん薬物療法 / 腎機能障害 / 薬物動態 |
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| Outline of Final Research Achievements |
We have studied the pharmacokinetics of cancer drugs and their metabolites in patients with renal dysfunction.
In patients with mild to moderate renal dysfunction, dose reduction of 5-FU is considered unnecessary according to renal function.However, we have reported that patients with severe renal dysfunction, such as those on hemodialysis, are at high risk of developing hyperammonemia due to accumulation of renal excretion of 5-FU metabolites (FBAL).We also examined the removal rate of oxaliplatin, a platinum-based drug that is representative of drugs with renal excretion, by dialysis and found that there was no difference in the removal rate when dialysis was performed on the same day as oxaliplatin administration or on a non-dialysis day.
Based on the above, we are now studying to establish an effective and safe administration method.
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| Free Research Field |
がん薬物療法
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、血液透析などの腎機能障害患者における5-FU及び白金製剤の薬物動態を明らかにすることにより、5-FU及び白金製剤の腎機能低下症例に対する適切な投与法を提案することが出来る。また、この成果は、軽度から中等度の腎機能障害患者にも応用することが可能と考えられ、罹患数の多い慢性腎障害患者でも適切に安全で有効ながん薬物治療を実施しすることにつながる。
現在まではエキスパートオピニオンにとどまっていたが、最終的には本研究結果をガイドライン改訂などに生かすことで、生命予後の延長に寄与することが期待される。
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