2019 Fiscal Year Final Research Report
A new treatment strategy for malignant glioma using spatially fractionated GRID radiation therapy
| Project/Area Number |
18K15279
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2020-03-31
|
| Keywords | 新規放射線治療 / グリッド照射 |
|---|
| Outline of Final Research Achievements |
This study was started with the aim of developing a new treatment using Grid. We created a size for a human. Based on information obtained from past literature and overseas conference, the size of holes, the distance between holes, the number of holes on the surface of the grid, the arrangement of holes, etc. were plotted. Based on this information, a metal processing contractor created a grid of a size that can be actually irradiated to people by using a lead material.
Next, it was necessary to confirm that the X-rays would pass through this grid correctly, so irradiation experiments using films were performed. The irradiation film analysis confirmed that the expected doses of valley dose and peak dose were expressed, and that irradiation was possible. In addition, the same experiment was performed by changing the energy or changing the electron beam and X-ray source, and it was confirmed that they passed through this hole without any problem.
|
| Free Research Field |
放射線治療
|
| Academic Significance and Societal Importance of the Research Achievements |
この人間用Gridの作成が完成し、そのGridが照射実験にて、予測通りのValley doseとPeak doseを表現できることが確認できたことにより、次に動物実験に移ることが可能である。当初はマウスを予定していたが、マウスサイズのグリッド作成は著しく困難であり、今後は豚に悪性神経膠腫細胞を埋植した上で、照射実験を行うことを考える。この実験により、このグリッド照射が現在治癒がほぼ不可能な悪性神経膠腫に対して、大量の放射線を照射することで重篤な有害事象を起こすことなく制御できることを期待できる画期的な治療になる。
|
