Epigenomic analysis of dedifferentiated liposarcoma

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K15328
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50020:Tumor diagnostics and therapeutics-related
• Research Institution: Keio University
• Principal Investigator: Asano Naofumi 慶應義塾大学, 医学部(信濃町), 講師 (10445299)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 肉腫 / 脂肪肉腫 / 脱分化型脂肪肉腫 / DNAメチル化 / 脱メチル化剤

Outline of Final Research Achievements

Dedifferentiated liposarcoma is a high-grade soft tissue sarcoma that predominantly affects in adults. In this study, we performed a comprehensive genomic DNA methylation analysis of well-differentiated and dedifferentiated liposarcomas. We found that DNA methylation of genes related to adipogenic differentiation may be involved in malignant transformation in highly malignant dedifferentiated liposarcomas. Our results suggest that demethylating agent therapy may be useful as a novel therapeutic strategy for dedifferentiated liposarcoma in the future.

Free Research Field

肉腫、骨軟部腫瘍

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、今後更なる前臨床研究が必須ではあるが、手術以外に有効な治療法が確立されていない、脱分化型脂肪肉腫の新規治療戦略となり得ることが期待される。