2020 Fiscal Year Annual Research Report
Shedding Light on the Role of Glia in Autism Spectrum Disorders(ASD) via Multifunctional Fibers
| Project/Area Number |
18K15337
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| Research Institution | Tohoku University |
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Principal Investigator |
郭 媛元 東北大学, 学際科学フロンティア研究所, 助教 (60815992)
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| Project Period (FY) |
2020-03-01 – 2021-03-31
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| Keywords | Multifunctional fibers / pH imaging in vivo / biochemical sensing |
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| Outline of Annual Research Achievements |
We have shown that multifunctional fibers with electrodes, optical waveguides and microfluidic channels are useful tools to investigate the astrocyte dynamics with neuronal activities in the anxieties and autism spectrum disorders. In this year, we focused on integrating biochemical sensing capabilities in fibers, which can enable the detailed analysis of chemicals in astrocyte-neuron interactions in various brain disorders. First, via integrating a functional component, i.e., the semiconductor based pH imaging sensor, with multifunctional fibers, we developed an all-in-one miniature pH microscope for visualizing intrinsic pH dynamics in deep brain structures. We were able to observe detailed pH changes in hippocampus in both health and diseased states of the brain with high spatial and temporal resolutions. In addition, we also synthesized new carbon nanotube (CNT) based composites and fabricated composite fibers that can be used for probing dopamine concentrations in brain. Currently we are able to detect dopamine concentration down to 10 nM in vitro settings. In this year, we have successfully integrated biochemical sensing modalities into multifunctional fibers, which can read in-brain pH and dopamine dynamics. In the future, we would like to further improve the fiber-based chemical probe with high spatial, temporal and chemical resolutions for the detailed investigation of brain chemicals.
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| Remarks |
郭 媛元 助教「トーキン科学技術賞 最優秀賞」を受賞
トーキン科学技術賞は、宮城県内の工学分野の若手研究者に贈られる賞であり、トーキン財団特別賞は、材料・部品分野の研究であって、先駆的研究を行った研究者、新境地を開いた研究者に贈られます。https://www.fris.tohoku.ac.jp/feature/topics/detail---id-891.html
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[Journal Article] Spatially expandable fiber-based probes as a multifunctional deep brain interface2020
Author(s)
Shan Jiang, Dipan C Patel, Jongwoon Kim, Shuo Yang, William A Mills, Yujing Zhang, Kaiwen Wang, Ziang Feng, Sujith Vijayan, Wenjun Cai, Anbo Wang, Yuanyuan Guo, Ian F Kimbrough, Harald Sontheimer, Xiaoting Jia
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Journal Title
Nature Communications
Volume: 11
Pages: 1-14
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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