2020 Fiscal Year Final Research Report
Investigation of lipid metabolism in Parkinson's disease
| Project/Area Number |
18K15376
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | Juntendo University |
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Principal Investigator |
Mori Akio 順天堂大学, 医学部, 非常勤助教 (60782878)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | パーキンソン病 / α-シヌクレイン / 神経変性疾患 / 脂質代謝異常 / リン脂質 / 異常タンパク質 / ショウジョウバエ / エクソソーム |
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| Outline of Final Research Achievements |
PLA2G6 gene is a causative gene of Parkinson's disease with α-synucleinopathy. We reported that PLA2G6-deficient Drosophila exhibits defects in neurotransmission, progressive cell loss, and aggregation of α-synuclein. Lipid analysis of the brain reveals that alternation in phospholipids. We reported these results Proceedings of the National Academy of Sciences of the United States of America (PNAS). Recently, we found abnormal exosomes from PLA2G6 knock-out cells. This result also suggests that lipid alteration leads to abnormal clearance.
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| Free Research Field |
神経変性疾患
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| Academic Significance and Societal Importance of the Research Achievements |
パーキンソン病は現在までのところ，疾患修飾治療は存在しない．我々は新たに脂質代謝に注目した．脂質改変により神経変性を予防することを動物モデルで明らかにしたことにより，疾患治療や食事を通した予防医学に通じる研究成果であると考える．
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