Translational research on brain aging and its modifiable factors using human and animal MRI

2019 Fiscal Year Annual Research Report

• Project/Area Number: 18K15410
• Research Institution: Tohoku University
• Principal Investigator: 鈴木 秀明 東北大学, 大学病院, 助教 (20705462)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: MRI / 脳 / UKバイオバンク / 加齢 / 生活習慣病 / 老化 / 認知症 / 高齢者

Outline of Annual Research Achievements

まず、臨床研究1.加齢と生活習慣病が脳に及ぼす影響の臨床研究に関する成果について、2018年7月に米国・シカゴで開催されたAlzheimer's Association International Conference 2018において学会発表「Suzuki H et al. Relative impacts of aging and modifiable risk factors for dementia on brain volumes in the UK Biobank cohort」を既に行っていたが、今回主要な結果に関し原著論文の形で報告した(Suzuki H et al. Associations of regional brain structural differences with aging, modifiable risk factors for dementia and cognitive performance. JAMA Netw Open 2: e1917257, 2019)。
次に、臨床研究２.脳の老化に関する新たな修正可能因子の探索については、2018年8月にドイツ・ミュンヘンで開催されたEuropean Society of Cardiology Congress 2018において既に学会発表「Suzuki H et al. Heart rate as a novel risk factor for brain health」を行い、当年度のYoung Investigator Award(population Sciences)を受賞していたが、芸イザイ原著論文への採択を目的に追加解析を行っている。
最後に、動物実験．加齢と生活習慣病が脳に及ぼす影響に関する機序の研究については、既に主要な結果が得られているが、追加実験・解析が必要であると考えている。
なお、2019年度における発表論文として、2本の第一著者論文(Suzuki H et al. Associations of regional brain structural differences with aging, modifiable risk factors for dementia and cognitive performance. JAMA Netw Open 2: e1917257, 2019; Suzuki H et al. Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure. Int J Cardiol in press)を含む計11本の論文が採択された。

Research Products

• [Int'l Joint Research] Imperial College London(英国)
  • Country Name: UNITED KINGDOM
  • Counterpart Institution: Imperial College London
• [Journal Article] Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure (2020)
  • Author(s): Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: in press Pages: in press
  • DOI: 10.1016/j.ijcard.2020.01.019
  • Peer Reviewed
• [Journal Article] Transcatheter aortic valve implantation and cognitive function in elderly patients with severe aortic stenosis (2020)
  • Author(s): Tsuchiya Satoshi, Matsumoto Yasuharu, Suzuki Hideaki, Takanami Kentaro, Kikuchi Yoku, Takahashi Jun, Miyata Satoshi, Tomita Naoki, Kumagai Kiichiro, Taki Yasuyuki, Saiki Yoshikatsu, Arai Hiroyuki, Shimokawa Hiroaki
  • Journal Title: EuroIntervention Volume: 15 Pages: e1580～e1587
  • DOI: 10.4244/EIJ-D-19-00489
  • Peer Reviewed
• [Journal Article] Large-scale Quality Control of Cardiac Imaging in Population Studies: Application to UK Biobank (2020)
  • Author(s): Tarroni Giacomo, Bai Wenjia, Oktay Ozan, Schuh Andreas, Suzuki Hideaki, Glocker Ben, Matthews Paul M, Rueckert Daniel
  • Journal Title: Scientific Reports Volume: 10 Pages: 2408
  • DOI: 10.1038/s41598-020-58212-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension (2020)
  • Author(s): Kozu Katsuya, Satoh Kimio, Aoki Tatsuo, Tatebe Shunsuke, Miura Masanobu, Yamamoto Saori, Yaoita Nobuhiro, Suzuki Hideaki, Shimizu Toru, Sato Haruka, Konno Ryo, Terui Yosuke, Nochioka Kotaro, Kikuchi Nobuhiro, Satoh Taijyu, Sugimura Koichiro, Miyata Satoshi, Shimokawa Hiroaki
  • Journal Title: Journal of Cardiology Volume: 75 Pages: 415～423
  • DOI: 10.1016/j.jjcc.2019.09.010
  • Peer Reviewed
• [Journal Article] Treadmill exercise prevents reduction of bone mineral density after myocardial infarction in apolipoprotein E-deficient mice (2019)
  • Author(s): Kanazawa Masanori, Matsumoto Yasuharu, Takahashi Kikuyo, Suzuki Hideaki, Uzuka Hironori, Nishimiya Kensuke, Shimokawa Hiroaki
  • Journal Title: European Journal of Preventive Cardiology Volume: 27 Pages: 28～35
  • DOI: 10.1177/2047487319834399
  • Peer Reviewed
• [Journal Article] Associations of Regional Brain Structural Differences With Aging, Modifiable Risk Factors for Dementia, and Cognitive Performance (2019)
  • Author(s): Suzuki Hideaki, Venkataraman Ashwin V, Bai Wenjia, Guitton Florian, Guo Yike, Dehghan Abbas, Matthews Paul M for the Alzheimer’s Disease Neuroimaging Initiative
  • Journal Title: JAMA Network Open Volume: 2 Pages: e1917257
  • DOI: 10.1001/jamanetworkopen.2019.17257
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease (2019)
  • Author(s): Konno Ryo, Tatebe Shunsuke, Sugimura Koichiro, Satoh Kimio, Aoki Tatsuo, Miura Masanobu, Suzuki Hideaki, Yamamoto Saori, Sato Haruka, Terui Yosuke, Miyata Satoshi, Adachi Osamu, Kimura Masato, Saiki Yoshikatsu, Shimokawa Hiroaki
  • Journal Title: PLOS ONE Volume: 14 Pages: e0225403
  • DOI: 10.1371/journal.pone.0225403
  • Peer Reviewed / Open Access
• [Journal Article] Automated quality control in image segmentation: application to the UK Biobank cardiovascular magnetic resonance imaging study (2019)
  • Author(s): Robinson Robert, Valindria Vanya V, Bai Wenjia, Oktay Ozan, Kainz Bernhard, Suzuki Hideaki et al.
  • Journal Title: Journal of Cardiovascular Magnetic Resonance Volume: 21 Pages: 18
  • DOI: 10.1186/s12968-019-0523-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders (2019)
  • Author(s): Evangelou Evangelos, Gao He, Chu Congying, Ntritsos Georgios, Blakeley Paul, Butts Andrew R, Pazoki Raha, Suzuki Hideaki et al.
  • Journal Title: Nature Human Behaviour Volume: 3 Pages: 950～961
  • DOI: 10.1038/s41562-019-0653-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Learning-Based Quality Control for Cardiac MR Images (2019)
  • Author(s): Tarroni Giacomo, Oktay Ozan, Bai Wenjia, Schuh Andreas, Suzuki Hideaki et al.
  • Journal Title: IEEE Transactions on Medical Imaging Volume: 38 Pages: 1127～1138
  • DOI: doi: 10.1109/TMI.2018.2878509
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Impacts of hippocampal blood flow on cardiac remodeling in patients with chronic heart failure (2019)
  • Author(s): Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Arai Hiroyuki, Taki Yasuyuki, Shimokawa Hiroaki
  • Organizer: 2019年度欧州心臓病学会
  • Int'l Joint Research
• [Presentation] Evidence for improved cognitive function following transcatheter aortic valve implantation in elderly patients with severe aortic stenosis - Brain perfusion SPECT imaging study (2019)
  • Author(s): Tsuchiya Satoshi, Matsumoto Yasuharu, Kikuchi Yoku, Sugisawa Jun, Hao Kiyotaka, Takeuchi Masashi, Takahashi Jun, Kawamoto Shunsuke, Kumagai Kiichiro, Wagatsuma Toshihiro, Saiki Yoshikatsu, Shimokawa Hiroaki
  • Organizer: 2019年度欧州心臓病学会
  • Int'l Joint Research
• [Presentation] 疣贅と類似した構造物を認めた、粘液腫様変性に伴う急性大動脈弁閉鎖不全症の一例 (2019)
  • Author(s): 佐藤匠、鈴木秀明、佐藤遥、矢尾板信裕、山本沙織、福井重文、建部俊介、杉村宏一郎、下川宏明
  • Organizer: 第169回日本循環器学会東北地方会
• [Presentation] Usefulness of Regional Wall Thickening Pattern for Differential Diagnosis of Cardiac Diseases with LV Hypertrophy -A Novel Deep-learning-based CMR System- (2019)
  • Author(s): Yamamoto Saori, Suzuki Hideaki, Bai Wenjia, Sugimura Koichiro, Tatebe Shunsuke, Aoki Tatsuo, Miura Masanobu, Sato Haruka, Konno Ryo, Terui Yosuke, Sakota Miku, Ota Hideki, Takanami Kentaro, Takase Kei, Nochioka Kotaro, Satoh Kimio, Shimokawa Hiroaki
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Transcatheter Aortic Valve Implantation Increases Regional Brain Perfusion Associated with Cognitive Improvement in Elderly Patients with Severe Aortic Stenosis (2019)
  • Author(s): Satoshi Tsuchiya, Yasuharu Matsumoto, Hideaki Suzuki, Jun Sugisawa, Tomohiko Shindo, Yoku Kikuchi, Kiyotaka Hao, Jun Takahashi, Kiichiro Kumagai, Yoshikatsu Saiki, Hiroaki Shimokawa
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Brain Areas Associated with Future Exacerbation of Heart Failure Symptoms (2019)
  • Author(s): Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
  • Organizer: 第83回日本循環器学会学術集会
• [Book] たこつぼ症候群における脳心連関 (2020)
  • Author(s): 鈴木秀明、松本泰治、下川宏明
  • Total Pages: 6
  • Publisher: 医歯薬出版株式会社