Investigation of the association between blood glucose variability and left ventricular diastolic dysfunction in high-precision continuous subcutaneous measurements

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K15436
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: TOCHIYA MAYU 国立研究開発法人国立循環器病研究センター, 病院, 医師 (80778697)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 2型糖尿病 / 心不全 / HFpEF / ケトン体

Outline of Final Research Achievements

In type 2 diabetic patients with some cardiac complications, treatment with an SGLT2 inhibitor, which has been shown to prevent HFpEF, resulted in a decrease in left ventricular end-diastolic diameter and an increase in flow-dependent vasodilatory response after 6 months.
The study also showed a decrease in left ventricular end-diastolic diameter and an increase in flow-dependent vasodilation response after 6 months. In addition, a correlation was observed between improvement in left ventricular diastolic performance (E/e ratio) and increases in ketone bodies (acetoacetic acid and 3-hydroxybutyric acid), suggesting that the increase in ketone bodies caused by SGLT2 inhibitors is associated with improvement in left ventricular diastolic performance.
Further studies will examine the relationship between sustained blood glucose levels and left ventricular end-diastolic diameter in type 2 diabetes mellitus.

Free Research Field

糖尿病・脂質代謝

Academic Significance and Societal Importance of the Research Achievements

近年増加し続ける糖尿病患者において、心不全合併を予防することは糖尿病患者の生命予後改善のために重要な課題である。ケトン体上昇は心筋微小循環を介した心筋代謝の改善効果も示されていることから、本研究の成果により、未だ有効な治療法が確立していないHFpEF全体に対する治療戦略解明へと発展する可能性が高まると考えられる。