APPLE (Association between the Pathology of Bipolar Disorder and Light Exposure in Daily Life) cohort study

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K15529
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Fujita Health University
• Principal Investigator: Esaki Yuichi 藤田医科大学, 医学部, 客員講師 (60793693)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 精神科 / 概日リズム / 睡眠 / 気分 / 光曝露

Outline of Final Research Achievements

The aim of this project is to clarify the association between the pathology of bipolar disorder and light exposure in daily life. I found that light exposure is significantly associated with depressive and manic symptoms, sleep quality, and circadian rhythm in patients with bipolar disorder.

Free Research Field

精神科

Academic Significance and Societal Importance of the Research Achievements

本研究結果により、日常生活の光曝露は双極性障害の病状（睡眠の質、うつ症状、躁症状、クロノタイプ、肥満、再発）と関連していることが明らかになった。双極性障害患者さんは、日中は可能な限り光を浴びて、夜間は真っ暗な部屋で眠ることが病状安定につながることが示唆された。