2020 Fiscal Year Final Research Report
Development of an orthotopic patient-derived pancreatic tumor xenograft (PDX) rat model and evaluation of treatment efficacy of interventional radiology
Project/Area Number |
18K15596
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Osaka City University |
Principal Investigator |
Kageyama Ken 大阪市立大学, 大学院医学研究科, 講師 (70791862)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Keywords | 膵癌 / 異種移植 / 免疫不全ラット / PDX / Interventional Radiology |
Outline of Final Research Achievements |
Patient-derived tumor xenograft (PDX) animal model is one of a screening platform in the world, which can be used to replace patients and provide cancer treatment in animals by transplanting patient-derived tumors removed from patients directly into immunocompromised animals. The purpose of this study is to increase the efficacy of transarterial chemo-infusion by establishing the PDX model in rats. We conducted two phase studies. (1) To create a liver metastasis model in which fresh patient-derived primary pancreatic cancer tumors removed by surgery are directly transplanted into the liver of immunodeficient rats; (2) To perform interventional radiology (IVR) treatments such as transarterial chemo-infusion in the model. We completined experiment 1. The primary pancreatic cancer tissue was able to be transplanted into the liver of rats. Next, we are currently conducting experiments to determine the anti-tumor effects of IVR treatment.
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Free Research Field |
放射線医学
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Academic Significance and Societal Importance of the Research Achievements |
患者腫瘍異種移植ラットモデルにおいて、それぞれの患者に見合った抗癌剤選択を可能とする癌治療スクリーニングプラットフォームの確立により、オーダーメイド治療の実践が期待される。
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