Mesenchymal stem cell for brain protection in the immature brain

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K15670
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Osaka Metropolitan University (2022-2023); Osaka City University (2021); Kobe University (2018-2019)
• Principal Investigator: Li Jingang 大阪公立大学, 大学院医学研究科, 特任講師 (90792458)
• Project Period (FY): 2021-03-01 – 2024-03-31
• Keywords: 間葉系幹細胞

Outline of Final Research Achievements

The effect of pregnancy-related hormones on the proliferation of mesenchymal stem cells (MSCs) was investigated, The results from this investigation suggest a high concentration of human chorionic gonadotropinigh （hCG) may prompt the proliferation of MSCs. The effect of hCG supplementation for MSC therapy for brain protection will be investigated in the next step.

Free Research Field

胎児新生児

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた結果をもとに、更に各種因子の間葉系幹細胞の増殖ないし機能的に与える影響を調査し、間葉系幹細胞の未熟脳に対する脳保護効果を最適化できるか調査していく。