2020 Fiscal Year Final Research Report
Basic study to evaluate the effectiveness of low-intensity pulsed ultrasound therapy for heart failure due to diastolic dysfunction.
| Project/Area Number |
18K15877
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 心不全 / 超音波治療 |
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| Outline of Final Research Achievements |
In the db / db mice treated with LIPUS therapy, the decrease in the left ventricular diastolic function and the decrease in exercise tolerance were suppressed. In addition, hypertrophy and fibrosis of the myocardium were suppressed, activation of Ca2 + handling-related proteins in the myocardium, and accompanying improvement in relaxation characteristics at the myocardial tissue level were observed. Furthermore, in protein expression analysis by Western-blotting, phosphorylation of endothelial NO synthase (eNOS) was significantly increased, and the increased expression of soluble guanylate cyclase and protein kinase G (PKG), which are downstream molecules of eNOS, was confirmed.
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| Free Research Field |
循環器内科学分野
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| Academic Significance and Societal Importance of the Research Achievements |
HFpEFは今や最も一般的なタイプの心不全となっており、世界中で最も深刻な健康問題の1つとして位置づけられている。HFpEFを対象とした多くの臨床試験が行われてきたが、いまだその予後を改善するための効果的な治療法の確立には至っていない。その様な状況の中、LIPUSが、血管内皮に直接働きかけ、eNOS-NO-cGMP-PKG経路の活性化を介してHFpEFの病態を改善することを動物モデルで実証することができた。HFpEFに対する有効な薬物療法がない中、超音波による物理刺激という従来の薬物療法とは全く異なるアプローチがHFpEFに有効であることが確認されれば、医学的意義は極めて高いものと考えられる。
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