2018 Fiscal Year Research-status Report
Effect of high fat diet and aging on lung stem cells
| Project/Area Number |
18K15934
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| Research Institution | Keio University |
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Principal Investigator |
尾崎 真理 慶應義塾大学, 医学部(信濃町), 研究員 (90772286)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | Lung stem cells / High fat diet / aging / alveolar cells |
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| Outline of Annual Research Achievements |
In the past year, we have examined previously-unexplored aspects of the negative effects of a HFD on lung stem cells. We have shown that 1)High fat diet (HFD) caused an increase in the number of alveolar type-2 cells. 2)Both aging and HFD caused an increase in inflammatory cell infiltration of the lung. 3)Both aging and HFD impaired various aspects of mitochondrial function. 4)HFD promoted in vitro colony formation by lung stem cells, while aging inhibited it. 5)Switching the diet to a low FD reversed several of the HFD-induced effects.
These results have been published as follows:'High fat diet activates adult mouse lung stem cells and accelerates several aging-induced effects'. Ozaki M et al. Stem Cell Res. 2018 Dec;33:25-35
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We have completed the first part of our study and have managed to publish. We are now looking more deeply into the mechanisms etc of the study.
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| Strategy for Future Research Activity |
We are now looking more deeply into the mechanisms of our study and are also looking into the effects of a high fat diet with specific lung diseases such as cancer and fibrosis
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