Elucidation of the pathophysiology of chronic obstructive pulmonary disease and control of inflammation and emphysema focusing on neuropeptide Y

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K15950
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Okayama University
• Principal Investigator: Taniguchi Akihiko 岡山大学, 医歯薬学総合研究科, 助教 (90751123)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: ニューロペプチドY / 慢性閉塞性肺疾患 / 肺気腫 / NPY / COPD / IL-17 / 3型自然リンパ球 / ILC3

Outline of Final Research Achievements

To clarify how neuropeptide Y is involved in airway inflammation and development of emphysema in chronic obstructive pulmonary disease (COPD), we utilized mouse elastase-induced emphysema model and evaluated the airway inflammation, respiratory function, and lung histology.
These data suggest the protective effects of NPY against elastase-induced airway inflammation and pulmonary emphysema in this model.

Free Research Field

呼吸器学

Academic Significance and Societal Importance of the Research Achievements

慢性閉塞性肺疾患（COPD）におけるニューロペプチドYの役割を調べた研究報告は未だなく、世界初の研究となる。
COPDのさらなる病態解明や新たな治療開発につながる可能性がある。