Role of cell adhesion molecule 1 (CADM1) in chronic kidney disease

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K16014
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Takashima Yasutoshi 京都府立医科大学, 医学部附属病院, 専攻医 (10797070)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 慢性腎臓病 / CADM1 / 尿細管間質炎 / NK細胞 / T細胞 / バイオマーカー

Outline of Final Research Achievements

Elevation of urinary CADM1 concentration was seen in the patient (n=44) based on various glomerulonephritis and nephropathy, but not in the rest of patients (n=83). Although urinary CADM1 concentration didn`t have no correlations with pathological tubulointerstitial injuries (epithelial degeneration, interstitial inflammation, and fibrosis), there was a weak inverse correlation between pathological injury scores and estimated glomerular filtration ratio. Notably, this correlation gradually increased in patients with high level CADM1 concentrations, and reached a maximum at a cutoff of 1,569 pg/ml. These results suggest that urinary CADM1 may be a useful marker indicating tubulointerstitial damage.

Free Research Field

腎臓病理学

Academic Significance and Societal Importance of the Research Achievements

尿中CADM1 shedding産物は尿細管でのCADM1 shedding状態を反映すると推定され、尿細管変性を直接的に推測しうる新マーカーとして意義深いと考える。今後、CADM1と相互作用を示すと推定されるCRTAM陽性細胞障害性Tリンパ球やCRTAM陽性NK（Natural killer）細胞の尿細管間質病変形成への関与を証明できれば、CADM1が慢性腎臓病の病態理解に新機軸をもたらすと期待される。