2022 Fiscal Year Final Research Report
Role of EpCAM function in skin and gut immunity
| Project/Area Number |
18K16038
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Keywords | EpCAM / 細胞接着分子 / 皮膚免疫 / 腸管免疫 |
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| Outline of Final Research Achievements |
Epithelial cell adhesion molecule (EpCAM) is essential for maintaining of intestinal stem cells. The function of EpCAM for skin immunity is now investigated by using imiquimod-induced psoriasis like dermatitis model.
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| Free Research Field |
皮膚科
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| Academic Significance and Societal Importance of the Research Achievements |
EpCAMの欠損は重度の腸管障害を引き起こす。EpCAMの機能を解析することで、治療法の開発に役立てることができる。また、EpCAMは皮膚免疫にも関与していると考えられ、皮膚免疫におけるEpCAMの機能を解明すれば、皮膚炎などの治療法の開発に貢献できる。
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