2021 Fiscal Year Final Research Report
Analysis of the role of Th2 cytokines in psoriasis
| Project/Area Number |
18K16041
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2021-03-01 – 2022-03-31
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| Keywords | IL-25 / Il-33 / 尋常性乾癬 / IL-1Ra |
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| Outline of Final Research Achievements |
IL-1Ra-GFP expression was observed in the keratinocytes of Il1rnGFP/GFP mice, but not wild-type mice. The production of IL-25 and IL-33 was higher in keratinocytes of skin lesions of Il1rn-/- mice than in those of wild-type mice. Intradermal administration of recombinant (r)IL-25 could induce inflammatory cell infiltrations, however, the population of IL-10+ dendritic cells was comparable between rIL-25-treated skin lesion and vehicle-treated skin lesion in Il10GFP/GFP mice.
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| Free Research Field |
皮膚科学分野
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| Academic Significance and Societal Importance of the Research Achievements |
尋常性乾癬は人口の約0.1~2%が罹患する慢性炎症性皮膚疾患であり、有病率は増加傾向にある。近年、TNFαやIL-17Aを標的とした抗体療法が重症患者に用いられ、治療の選択肢は広がっている。尋常性乾癬の病変部では、Th2サイトカインであるIL-25とIL-33の発現がみられるが、詳細な機能は不明である。IL-25とIL-33と尋常性乾癬の症状との関係を解明することは、難治性病変に対する治療に役立つと考えた。
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