2020 Fiscal Year Final Research Report
The effects of HNRNPM in pancreatic cancer under the hypovascular environment
| Project/Area Number |
18K16216
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Hiroshima International University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 膵臓がん / HNRNPM / MIA PaCa-2 |
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| Outline of Final Research Achievements |
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is a splicing factor that plays an important role in the regulation of gene expression by processing heterogeneous nuclear RNAs into mature mRNAs. HNRNPM was highly expressed in pancreatic tissues but expression decreased in pancreatic ductal adenocarcinoma tissues. Furthermore in this study, we found that knockdown of HNRNPM protein expression under low-glucose conditions altered glucose metabolism and prolonged cell survival by suppressing glucose consumption.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
我が国における膵臓がん患者の生存率は、極めて低い。これは、膵臓がんの早期発見が困難であることに加え、他のがんと異なり一般的に乏血性環境下（血流が乏しく酸素や栄養供給が少ない環境）でも生存可能なメカニズムを持つことに起因している。そのため、この乏血性環境耐性メカニズムに対する特効薬の開発が望まれているが、その獲得機構については未だ解明されていない。今回の研究成果は抗癌剤および早期診断マーカー開発に向けた基礎の研究であり、この研究が更に進展すれば膵臓がん患者のQOL向上に役立つ可能性が高い。
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