Elucidation for epigenetic mechanism of Abscopal effect in rectal cancer after CRT

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K16279
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: Mie University
• Principal Investigator: Ide Shozo 三重大学, 医学部附属病院, 医員 (90616088)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 直腸癌 / 化学放射線療法 / アブスコパル効果

Outline of Final Research Achievements

It is difficult to elucidate for abscopal effect with radiation therapy, because we could not make the mouse model with rectal cancer metastases. Otherwise, in Kaplan-Meier analysis, both overall survival (OS) and disease-free survival (DFS) were shorter in the low GNRI group, the high P-CRP group, the low LCR group, and the high RDW group in rectal cancer patients undergoing preoperative chemoradiotherapy. Our study showed that these new markers are useful to identify poor prognosis and recurrence in rectal cancer patients undergoing preoperative chemoradiotherapy.

Free Research Field

消化器外科学

Academic Significance and Societal Importance of the Research Achievements

本研究結果を用いることで、直腸癌化学放射線療法における新たな予後マーカーの可能性が示唆された。