2020 Fiscal Year Final Research Report
Development of novel gene-modified T cell transfer therapy by tumor reactivity analysis of colorectal cancer infiltrating T cells
| Project/Area Number |
18K16301
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 遺伝子改変T細胞移入療法 / 免疫療法 / 腫瘍浸潤リンパ球 / がん特異的TCR |
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| Outline of Final Research Achievements |
Analysis of tumor-infiltrating lymphocytes revealed that TCRs that proliferated clonally were present in the tumor-infiltrating lymphocytes. A specific TCR that responds to tumors cultured using the Cancer tissue-originated spheroid method could be found in the TCR.
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| Free Research Field |
外科
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| Academic Significance and Societal Importance of the Research Achievements |
がん免疫療法の1つであるTCR-T細胞療法は、がん特異的TCR遺伝子を用いた遺伝子改変T細胞移入療法であるが、この療法では患者のがん細胞に特異的なTCR遺伝子が必要である。従来の方法では、TCR遺伝子の取得に多大な労力と時間を必要としていたが、今回の研究成果により簡便・迅速ながん特異的TCR遺伝子を取得することがで出来、治療効果の高い個別化TCR-T療法の臨床応用が可能となる可能性がある。
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