Developing integrated approaches for the treatment of refractory tumor microenvironment

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K16377
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Okayama University of Science (2019); National Cancer Center Japan (2018)
• Principal Investigator: Nakajima Kosei 岡山理科大学, 獣医学部, 講師 (80785775)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 難治性がん / 微小環境 / トランスレーショナル・リサーチ

Outline of Final Research Achievements

Non-curable tumors, including pancreatic cancer and musculoskeletal tumors, remains clinically challenging, and requires the identification of new molecular target that can be therapeutically exploited to improve patient outcome. Here, our studies demonstrate that a candidate molecule shapes the refractory tumor microenvironment through stratified experimental approaches, i.e. clinical patient data, pathological analysis, cell-molecular-genome analysis, bioinformatics, compound screening, and mouse models. The results highlight a drug suggesting a potential therapeutic strategy, “Normalization of tumor microenviroment” for mitigating refractory tumors. Thus, our new outlook suggests delivering a novel treatments, providing a hope to patients afflicted with non-curable tumors.

Free Research Field

外科関連

Academic Significance and Societal Importance of the Research Achievements

今回得られた成果は、難治性のがんに苦しむ患者さんにとって、治癒のための一筋の光明となる可能性がある。