Role of periostin in lung cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K16432
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55040:Respiratory surgery-related
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Takahashi Rie 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 共同研究員 (00773954)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 肺癌

Outline of Final Research Achievements

Tumor microenvironment is composed of cancer and stromal cells, and their relationship increased the tumor development. We elucidated that periostin, which is expressed in stromal cells, increased the tumor malignancy in lung cancer. Tumor formation in primary and metastatic lesions decreased in periostin knockout mice. Recombinant periostin increased the migration capacity of cancer cells. Collectively, periostin aids tumor development in lung cancer.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

肺癌におけるあたらしい予後不良因子を同定した。今後の肺癌治療開発における基礎データを得ることができた。