Association between nutrition and ICU - acquired weakness : a prospective cohort study.

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K16439
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Masuda Takahiro 東京医科歯科大学, 東京医科歯科大学病院, 助教 (40594635)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 集中治療医学 / 気道確保 / 栄養療法

Outline of Final Research Achievements

Nutrition therapy is regarded as an important role in longitudinal outcome of critically ill patients, but the effect of nutrition therapy on clinical outcome is unknown. This study is conducted to reveal the association between them, but the study is faced to the difficulty in the pandemic of Corona Virus Infectious Disease 2019 (CoVID-19), because exhaled gas, which is needed in this study becomes not available.
In this difficulty, I decided to change the plan of study, and I conducted the retrospective observational cohort study, which revealed the association between airway management techniques and peri-intubation complications.

Free Research Field

集中治療医学

Academic Significance and Societal Importance of the Research Achievements

結果的にこの研究では当初計画していた栄養療法の研究を遂行することはできなかったが、代替として実施した気道確保の研究で、意識下挿管が気管挿管に伴って発生する重篤な合併症を大幅に予防しうることを見出すことができた。重症症例における気道確保は、栄養療法と同じ程度に重要な研究課題であることから、本研究をきっかけとして、軌道確保、特に意識下挿管が重症症例にもたらす影響について、今後研究を発展させる方針である。