Involvement of endoplasmic reticulum stress in hypoxic ischemic encephalopathy

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K16473
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Chiba University
• Principal Investigator: kokubun hiroshi 千葉大学, 医学部附属病院, 助教 (50782695)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: オピオイド / 痛覚過敏 / 小胞体ストレス / 吸入麻酔薬

Outline of Final Research Achievements

Although different from the original plan, we created a pain-sensitive model mouse by intermittently administering remifentanil to wild-type mice, and examined the effect of endoplasmic reticulum stress on opioid-induced hyperalgesia (OIH). An experiment was conducted. It was suggested that administration of chemical chaperones such as Sodium phenylbutyrate (4-PBA) and Tauroursodeoxycholic acid (TUDCA) to pain-sensitive model mice may suppress pain-sensitivity.
We also studied the neuroprotective effect of inhalational anesthetics, neurotoxicity, and endoplasmic reticulum stress, and published it as a paper.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

オピオイドはがん疼痛などに非常に有用な鎮痛薬であるが、乱用による中毒や副作用が問題となることもある。オピオイド投与によって誘発される疼痛過敏(opioid induced hyperalgesia:OIH)は、まだメカニズムが不明な部分も多く、治療法も確立されていない。我々の研究は、OIHと小胞体ストレス反応の関連を明らかにし、化学シャペロンの投与によってOIHが抑制される可能性を示唆している。