Hyperbaric oxygen therapy affect tissue drug concentration

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K16534
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: Gifu University
• Principal Investigator: Kanda Norihide 岐阜大学, 医学部附属病院, 助教 (40421177)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 高気圧酸素療法 / 組織中薬物濃度

Outline of Final Research Achievements

In the clinical practice, the antibiotics dosage is decided based on PK (pharmacokinetics) /PD (pharmacodynamics) theory. However, this theory does not work in the organ failure and necrotic tissue. Although the hyperbaric oxygen therapy is used in several clinical practices, the mechanisms is not unknown. The aim of the current study is to confirm that the hyperbaric oxygen therapy affect tissue drug concentration.

Free Research Field

救急集中治療医学

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、HBOTによるPK/PDに影響する遺伝子解析を行い、HBOTの薬物濃度増強効果を確かなものとすることである。これは救急領域におけるHBOの普及につながる可能性を持ち、救急分野におけるインパクトは非常に大きい。