• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2019 Fiscal Year Final Research Report

Investigation of relationship between osteosarcoma and immune cells

Research Project

  • PDF
Project/Area Number 18K16652
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionShinshu University

Principal Investigator

Yoshida Kazushige  信州大学, 医学部, 特任助教 (60770774)

Project Period (FY) 2018-04-01 – 2020-03-31
Keywords骨肉腫 / 抗PD-1抗体 / Wnt
Outline of Final Research Achievements

In this research, we evaluated the efficacy of anti-PD-1 antibody for osteosarcoma and the dynamics of immune cells in tumor microenvironment. According to the results, the long-term administration of anti-PD-1 antibody suppressed the increase of tumor volume and improve the overall survival in the osteosarcoma heterotopic transplantation model mouse. Also, the regulatory T cells (Treg) especially the activated Treg(Ki67+) decreased by the administration of anti-PD-1 antibody.
On the other hand, Wnt3a, Lrp5 and Wnt5a positive are correlated in the clinical specimen of osteosarcoma.

Free Research Field

整形外科

Academic Significance and Societal Importance of the Research Achievements

本研究結果は、抗PD-1抗体が骨肉腫の腫瘍体積の増加を抑制し、全生存率を改善することを示した。また、抗PD-1抗体投与により腫瘍内のTregが減少することが分かり、抗PD-1抗体の抗腫瘍効果における新しいメカニズムを示唆している。これらの研究成果は骨肉腫の治療における抗PD-1抗体を考えるうえで重要な基礎データとなる。また、臨床検体を用いた検討の結果は骨肉腫においてWnt古典経路及び非古典経路が協調的に働いている可能性を示しており、病態の理解やそれに伴う新規治療法の確立において有用な結果である。

URL: 

Published: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi