Elucidation of castration-resistant prostate cancer mechanism via hedgehog pathway

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K16716
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Osaka Medical College
• Principal Investigator: Ibuki Naokazu 大阪医科大学, 医学部, 講師 (90368100)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 去勢抵抗性前立腺癌 / Enzalutamide / Hedgehog

Outline of Final Research Achievements

Pharmacotherapy for castration-resistant prostate cancer has been developing in recent years with the advent of new drugs. However, the drug will eventually become ineffective and new drugs are expected to appear.
Our study suggests that the Hedgehog pathway may be involved in Enzalutamide resistance, one of the drug therapies for castration-resistant prostate cancer, and will lead to the development of new drugs for castration-resistant prostate cancer. It was considered.

Free Research Field

前立腺癌

Academic Significance and Societal Importance of the Research Achievements

去勢抵抗性前立腺癌のメカニズムおよび去勢抵抗性前立腺癌に対する薬物療法（Enzalutamide）抵抗性のメカニズムを検討するため、癌細胞を用いてHedgehog経路が関与しているかどうかの実験を行った。
結果、Hedgehog経路を抑制することで去勢抵抗性前立腺癌およびEnzalutamide抵抗性前立腺癌に対して治療効果が発揮されることを確認した。今後の新薬開発につながるものと考えられる。