Analysis of the role of laeverin expression in fetal-placental circulating stem cells derived from chorionic villi

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K16793
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: Kanazawa University
• Principal Investigator: Matsumoto Takeo 金沢大学, 附属病院, 特任助教 (30748629)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: laeverin / 胎児・胎盤循環幹細胞 / 免疫寛容

Outline of Final Research Achievements

Recently, we found that laeverin may be expressed on fetal-placental circulating stem cells derived from chorionic villi. Since human angiogenesis in the chorionic villi occur earlier than those in the fetus, chorion-derived stem cells may be transferred to the fetal tissues by the circulatory system. The purpose of this study was to elucidate the role of laeverin-positive cells as immune regulatory cells and stem cells. In this project, laeverin was expressed in some of the CD34-positive cells in chorionic villi stromal tissue and cord blood, and its expression may be involved in immune regulation.

Free Research Field

腫瘍　生殖医学

Academic Significance and Societal Importance of the Research Achievements

本研究は絨毛由来で循環系を介して胎児に移行し、生着する幹細胞の候補としてlaeverin陽性細胞を提案しており、本研究の成果によってlaeverin陽性細胞の免疫制御細胞や幹細胞としての役割が推察でき、将来の生殖医学・周産期学のみならず、臓器移植や再生医療における臨床応用に有益な知見を得ることが期待できる。