Analyzing lipid-metabolizing enzymes under endoplasmic reticulum stress in inner ear cells and elucidating the cause of sensorineural hearing loss

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K16829
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Yamagata University
• Principal Investigator: Matsui Hirooki 山形大学, 医学部, 助教 (60594322)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 内耳障害 / 感音難聴 / コルチ器 / 脂質代謝酵素 / ジアシルグリセロールキナーゼ / 有毛細胞 / らせん神経節

Outline of Final Research Achievements

Acoustic exposure in guinea pigs showed that DGKζ translocated from the nuclei into the cytoplasm in outer hair cells. DGKζ was present in the nuclei in the spiral ganglion cells, but acoustic exposure did not change its intracellular localization. In addition, we reported that the hearing threshold of Alport syndrome was increased for long-term observation, which is a sensorineural hearing loss disease. We also reported that a government program in the purchase of hearing aids for children with mild or moderate hearing loss is useful.

Free Research Field

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Academic Significance and Societal Importance of the Research Achievements

リン脂質代謝酵素に内耳における音響暴露における細胞内局在について解析し論文として報告した。感音難聴疾患について臨床研究を行い論文で報告した。