Studies on the causative fungi of fungal sinusitis and disease control by analysis of microbiota

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K16853
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Tohoku University
• Principal Investigator: Risako Kakuta 東北大学, 大学病院, 助教 (40596095)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 副鼻腔真菌症

Outline of Final Research Achievements

This study was conducted with the aim of controlling the disease by identifying the causative fungi of fungal sinusitis and clarifying its microbiological characteristics. In this study, both invasive and non-invasive fungal sinusitis were included. The causative fungis were identified by genetic analysis. Microbiota analysis revealed that the microbiota is composed of various bacterial species.

Free Research Field

耳鼻咽喉科感染症

Academic Significance and Societal Importance of the Research Achievements

これまで、副鼻腔真菌症の原因真菌を菌種レベルで明らかにした報告はほとんど見られなかったが、本検討において副鼻腔真菌症の主な原因真菌が菌種レベルで明らかとなった。さらに副鼻腔真菌症の微生物叢についても明らかになった。近年高齢化や疾患および治療が多様化しており、副鼻腔真菌症は今後も増加することが考えられる。本検討結果は、今後の副鼻腔真菌症の治療のさらなる発展に貢献できることが期待される。