Biochemical and behavioral approach against inner ear disorder and development of new therapeutic modality

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K16909
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56050:Otorhinolaryngology-related
• Research Institution: Nippon Medical School
• Principal Investigator: Kato Taisei 日本医科大学, 医学部, 助教 (80787523)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 内耳性難聴 / 急性感音難聴 / 蝸牛 / Erk / 細胞死

Outline of Final Research Achievements

It became clear now that seriously worse hearing impairment occurred in the knockout mouse by powerful sound load when manufacture of the inner ear-specific conditional knockout mouse of Erk2,FRS2 was almost completed, and it analyzed the hearing function.Also, this this inner ear-specific conditional knockout mouse confirmed that there was not the morphologic abnormality particularly.
Also, we confirmed that the expression of downstream AP-1 of the signal of FRS2 increased.

Free Research Field

内耳生化学

Academic Significance and Societal Importance of the Research Achievements

内耳特異的Erk1/2およびFRS2コンデイショナルノックアウトマウスの聴覚特性の解析することにより、内耳障害を引き起こす可能性のある分子ネットワークを網羅的に解析、検討することが可能となり、内耳障害の診断と治療、またその進行の独創的な予防法が明らかになると考えられる。