Neuroprotection using animal models of glaucoma

2019 Fiscal Year Final Research Report

• Project/Area Number: 18K16972
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56060:Ophthalmology-related
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: AKIYAMA Goichi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (00529547)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Keywords: 緑内障 / 神経保護 / 房水流出

Outline of Final Research Achievements

In this study, we examined the effects of a chemical compound that suppresses oxidative stress in a mouse model of glaucoma. We found that it may exert neuroprotective effects. We also found that most of the angiographic aqueous humor outflow was seen in the nasal area by using a new imaging technique.

Free Research Field

眼科学

Academic Significance and Societal Importance of the Research Achievements

今回の研究では内服治療などの神経保護療法が、緑内障の進行抑制に有効な可能性を示した。また従来通りに眼圧降下手術を行う場合にも、より効率的な手法があることを示すことができた。