Investigation of new treatment for diabetic ulcer with the biodegradable scaffold

2023 Fiscal Year Final Research Report

• Project/Area Number: 18K16991
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Nagoya City University
• Principal Investigator: SATO HIDEYOSHI 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (70528968)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Keywords: 組織工学 / 形成外科 / 難治性潰瘍

Outline of Final Research Achievements

The cellularized, elastic, biocomposite scaffold (Extracellular matrix: ECM + Poly(ester-urethane) Ureas: PEUU) was transplanted to the thigh of rat to evaluate the ability of tissue regeneration. The expressions of RNA related with nerve regeneration had no significant differences among the experimental group, negative and positive control groups. The nerve elongation into the transplanted materials were observed in the immunohistochemistrial samples. Muscle regeneration were also observed and the strength of regenerated muscle was recovered stronger than preoperative values. The material used in this experimental study should be one of the effective treatment for refractory ulcers represented by diabetic skin ulcers.

Free Research Field

形成外科

Academic Significance and Societal Importance of the Research Achievements

高齢化社会が進むに従い、糖尿病の治療も長期化し、それに伴う合併症の増加も今後見込まれている。中でも足を中心とした、糖尿病性足潰瘍については難治性で、患者本人の苦痛や医療資源の増大につながる合併症であり、有効な治療法の開発が望まれる分野である。本研究に使用した、生体親和性のマテリアルは組織再生を誘導させ、皮膚潰瘍などの治癒を促進させうる可能性が示唆された。臨床応用され、組織再生能力が確認されれば、前述の医療資源の削減にもつながり、社会貢献の一助を担う可能性があると考えている。